CD126 Antibody BMS135 from Thermo Fisher Scientific

Published Figures

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Cellular and molecular gastroenterology and hepatology
May 01 2016

Fig 1: IL6 up-regulates KIAA1199 deposition into the ECM of colon fibroblasts. (A) Average fold-change between densitometric measurements of immunoblots measuring KIAA1199 protein in the ECM of cytokine-stimulated and unstimulated ND colon fibroblasts. Five independent experiments using 5 cell lines are shown. (B) Average fold-change between densitometric measurements of immunoblots measuring KIAA1199 protein in the ECM of IL6-stimulated and unstimulated CD colon fibroblasts. Four independent experiments using 4 cell lines are shown. (C) Comparison of IL6 protein levels in the conditioned media of CD and ND colon fibroblasts after 13 days of growth. Enzyme-linked immunosorbent assay determination of supernatants from 5 ND and 4 CD cell lines is shown. (D) Average densitometric measurements of immunoblots measuring KIAA1199 protein in the ECM of IL6R-blocking antibody–treated, mouse IgG-treated, and untreated CD colon fibroblasts. Five independent experiments using 5 cell lines are shown (*P < .05, **P < .01). Ab, antibody.
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Cell death & disease
January 20 2021

Fig 2: IL-6 promotes KIAA1199 expression through the PI3K/Akt/NF-κB signaling pathway in RA FLS.A–D Relative mRNA expression of KIAA1199 in FLS from healthy subjects (n = 9) stimulated without (Control) or with 1 and 5 ng/ml TNF-α (A), IL-1β (B), IL-6 (C), and TGF-β1 (D), respectively. E–G Inhibitory effect of IL-6R blocking mAb on the expression of KIAA1199 mRNA (E), protein (F) in FLS from RA patients (n = 9), and the formation of LMW-HA in the medium (G). H Western blot analysis of cytoplasmic PI3K, p-Akt, toatl-Akt, p-STAT3, total-STAT3, and intranuclear p-P65 in RA FLS stimulated with 5 ng/ml IL-6 at 0, 15, 30 min. I Effect of ly294002, GSK690693, and Stattic on the mRNA expression of KIAA1199 in response to 1 ng/ml IL-6. J, K Effect of siRNA knockdown of PI3K (J) and STAT3 (K) on the protein expression of KIAA1199 in RA FLS stimulated without or with 1 ng/ml IL-6. All reactions were conducted in triplicate and the data were presented with mean ± SD.

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Thermo Fisher Scientific for
CD126 Antibody

The CD126 Antibody from Thermo Fisher Scientific is a Mouse Monoclonal antibody to IL6R, and Interleukin 6 Receptor. This antibody recognizes Homo Sapiens, and Human antigen. The CD126 Antibody has been validated for the following applications: Assay, Flow Cytometry, and Functional Assay.

Cellular and molecular gastroenterology and hepatology

Cell death & disease

CD126 Antibody from Thermo Fisher Scientific

Thermo Fisher Scientific

Citations (4)

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CD126 Antibody from Thermo Fisher Scientific

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